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We examine the role of receptor binding kinetics and -arrestin-biased signaling in the observed trafficking profiles, identifying a linked set of agonist characteristics optimally suited for insulin secretion, not shared by GLP-1R agonists in the current clinical use

Yancey, A

Headaches represent a recognised and common adverse effect, affecting approximately 1314% of patients in clinical trials

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Exenatide was derived from the exendin-4 protein, a functional analog of GLP-1, isolated from Gila monster venom (7)

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