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doi: 10.1152/physrev.00031.2014 265 StregeP

There is no established pharmacologic mechanism by which GLP-1 receptor agonism would directly cause musculoskeletal pain

Your body produces GLP-1 in short bursts after eating, and the hormone breaks down quicklywithin minutes
Metformin typically achieves A1C reductions of 1.0-1.5% as monotherapy, depending on the baseline level

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Heymsfield SB, Brown J, Ramirez S, et al
