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327 QRTPCR analysis also demonstrated that Lnc78583 overexpression upregulated HOXB13 and IL-10 to inhibit inflammation by inhibiting the binding of miR3202 to HOXB13, indicating that Lnc78583 has a protective effect on lipopolysaccharide-induced UC inflammation by targeting HOXB13

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Among these serious adverse effects, AP has raised additional concerns, as MASLD clearly increases the risk of incidence and severity

However, these observational studies have inherent limitations, including potential residual confounding (as some registries lack complete data on important cancer risk factors like smoking), selection bias, and the challenge of detecting rare events