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Diabetes 59:11171125 Xu G, Kaneto H, Laybutt DR et al (2007) Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes

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Individuals with severe chronic kidney disease (eGFR below 15 mL/min/1.73m) or those on dialysis face potential risks from semaglutide because GLP-1 effects on renal perfusion and fluid balance are not fully characterized in end-stage renal disease

doi: 10.1038/ijo.2011.158 89 AstrupARssnerSVan GaalLRissanenANiskanenLAl HakimMet al
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