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doi:10.1016/j.bbrc.2012.08.072 81

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Tirzepatide and retatrutide (single molecule): A single engineered molecule that hits multiple receptors simplifies the formulation to one compound with one pharmacokinetic profile, and allows the balance of receptor activation to be tuned at the molecular-design level
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While Orforglipron and amycretin are still in the clinical trial phase, another promising candidate is further along
