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This illustrates the elegant complexity of GLP-1RA signalling, where a single class of drugs can exert distinct, beneficial effects in different cell types within the cardiovascular system, leading to a comprehensive protective profile (Figure 2) [10,23]
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GLP-1 receptor agonists are widely prescribed for diabetes because of their glucose-lowering, weight-reducing and cardiovascular benefits
Historically, neuropathy endpoints were not primary outcomes in major diabetes trials
The Risk of Constipation Constipation is one of the most frequently reported side effects of semaglutide
