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30 , 61429 doi: in press (2016)
10.1210/en.2011-1443 3 BaisleyS

GLP-1 drugs were originally developed to treat type 2 diabetes, but several are now approved for chronic weight management: Wegovy (semaglutide), which is available as a pill or injection Zepbound (tirzepatide) injection Saxenda (liraglutide) injection Impact of Obesity on MS Progression Benefits of Weight Loss for People With MS Together, these findings suggest that weight loss may positively influence inflammation and symptoms relevant to MS, even though long-term effects on disease progression are still unclear, says Ali

Yerba mate does not directly increase glucagon-like peptide-1 (GLP-1) production in meaningful clinical amounts

Although GLP-1 RA therapy has shown promising results for preserving lean mass and even muscle quality compared to fat mass, the trajectory of muscle mass and function following weight regain remains uncertain [98]

GLP-1R/GIPR/GcgR triple-agonists are still early in the developmental process, as addressing potential safety concerns and further clinical trials are needed [123]
