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Tirzepatide Once Weekly for the Treatment of Obesity | New England Journal of Medicine Note: the FDA considers body composition metrics to be safety endpoints which often results in underpowered secondary endpoints in Phase 3 registration trials

Ben Nasr M, Usuelli V, Dellepiane S, Seelam AJ, Fiorentino TV, DAddio F, et al

But GLP-1 isn't new, and it isn't synthetic

We investigated how GLP-1RAs impact weight changes in patients who underwent bariatric surgery compared to a placebo arm

Without proper nutrition, this loss of rapid burning of calories can also lead to bone density loss

We have a line of sight that is telling us, you know what, in the brain of people who are living with mental illness, again, mental illness is a big category but mental illnesses broadly, is that theres something not quite right with how the brain cells are utilizing energy