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In addition to aiding in weight loss, GLP-1 agonists can improve blood sugar control and offer cardiovascular and kidney health benefits, particularly for those managing diabetes

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As 2024 drew to a close, Englands NICE finalised its guidance for Mounjaro, recommending its use in the primary care setting, for treating adults with a body mass index (BMI) 35 kg/m2 and at least one weight-related co-morbidity, alongside a reduced-calorie diet and increased exercise, with no restriction on treatment duration, equating to a total eligible population of 3.4 million patients [5]

Even so, there is still limited or uncertain evidence about their long-term safety, possible side effects, and how financial ties might influence study results

Preliminary cardiovascular outcome data on tirzepatide in type 2 diabetes The above-mentioned preliminary cardiovascular safety data from the SURPASS-4 study demonstrated no excess cardiovascular risk associated with tirzepatide therapy (54, 73)

[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Sandoval D.A., D'Alessio D.A