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People with CKD stages 13 have significantly elevated cardiovascular risks compared to the general population, while nearly half of those with CKD stages 45 experience CVD [5]

PMID: 41173056 Biochem Pharmacol Exendin-4 Prevents oxLDL-Induced upregulation of TREM2 and attenuates foam cell formation and inflammation in Macrophages

80 While the clinical significance of this heart rate increase remains uncertain, it raises theoretical concerns in patients with ischemic heart disease or arrhythmias and may counteract some of the antihypertensive benefit of GLP-1 RAs

Griauzde DH, Ibrahim AM, Fisher N, Stricklen A, Ross R, Ghaferi AA

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Drugs like semaglutide are engineered copies of that hormone, tuned to last a week in the body instead of a few minutes