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The mechanism is not entirely clear, but B12 plays a role in nervous system function and neurotransmitter synthesis, which may help modulate the nausea response triggered by GLP-1 receptor activation in the brainstem

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So I still find that using a phenotypic approach even with pharmacotherapy can be very advantageous for the patients because it really rounds out: how do I treat the patient in front of me, even though it's the same medication I use for the past five patients

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