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doi: 10.1016/j.cmet.2013.04.008 2 NauckMAMeierJJ

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Semaglutide treatment also resulted in a reduction in BMI and waist circumference

[1] [2] This binding triggers several physiological responses: Enhanced insulin secretion : Ozempic stimulates the pancreatic beta cells to release insulin, but only when blood glucose levels are elevated, which reduces the risk of hypoglycaemia [1] [2] Suppressed glucagon release : It inhibits the secretion of glucagon, a hormone that raises blood glucose by promoting hepatic glucose production Delayed gastric emptying : The medication slows the rate at which food leaves the stomach, leading to more gradual glucose absorption Reduced appetite : Ozempic acts on appetite centres in the brain, promoting satiety and often resulting in weight loss Ozempic is available in multi-dose pre-filled pens for weekly administration

Revised: November 2025 Instructions for Use WEGOVY HD INSTRUCTIONS FOR USE SECTION Instructions for Use WEGOVY HD (semaglutide) injection WEGOVY HD comes in the following strength: Before you use your WEGOVY pen for the first time , talk to your healthcare provider or your caregiver about how to prepare and inject WEGOVY correctly