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A subset of CD8 T cells also express GLP-1R when exhausted

Whereas previous research has demonstrated the feasibility of using peptides to target nuclear hormone receptors 46,47 , to our knowledge, this is the first single molecule that uses a G-protein-coupled-receptor targeting approach to deliver a small-molecule modulator of an ionotropic receptor

GLP-1 microdosing uses a smaller, clinician-guided dose instead of quickly moving to a standard maintenance dose

Neurol Clin Pract 2021;11:e504-7

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Vascular located monocytes/macrophages engulf oxidized-LDL (ox-LDL), generating foam cells which release a plethora of pro-inflammatory mediators