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Description
Insulin sensitivity changes alter carbohydrate metabolism
We predicted that ghrelin increases the willingness to exert instrumental effort, which will be reflected in changes in brain responses within the motivational circuit
Clinical trials show sustained weight loss over 68 weeks with ongoing therapy
Key Upcoming Milestones Phase 2 COURAGE Readout: Expected 2H 2025, potentially as early as mid-Q3, with a key focus on fat-to-muscle loss dynamics
Body weight reduction in this trial equates to 3.4%, 4.3%, and 3.7%, respectively, and 0.2% in the placebo group (94)
They leave out the practical details that actually matter when you are standing in your kitchen with a syringe and a vial, trying to figure out whether 12.5 units or 25 units is the right draw for your prescribed dose
