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This has led researchers to investigate medications that modulate these systems, including the glucagon-like peptide-1 (GLP-1) receptor agonists originally developed for type 2 diabetes and obesity management

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As several GPCR natural ligands are cyclic peptides such as calcitonin, oxytocin and somatostatin 15 , two libraries encoding cyclic peptide N termini (either randomized tetrapeptide (CX 4 C), or pentapeptide (CX 5 C)) were designed (Fig

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