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Slows Digestion : By slowing down the rate food leaves the stomach, GLP-1 helps reduce how fast glucose is absorbed into the bloodstream, which reduces blood sugar spikes after eating

He points to a clinical trial published in The New England Journal of Medicine studying the impact of semaglutide in people who were diagnosed with both overweight or obesity and heart disease, but who had no history of diabetes

Orforglipron efficacy According to the phase 3 ATTAIN1 clinical trial, people with obesity and overweight (without diabetes) who used the highest dose (36 mg) of orforglipron (an oral glucagon-like peptide1 receptor agonist) lost approximately 12.4% of body weight after 72 weeks