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Both medications are commonly covered by insurance for the treatment of type 2 diabetes, but coverage may vary when prescribed for off-label purposes, such as weight loss

Calpain-2 has been implicated in the pathogenesis of ALS based on findings of elevated levels of calpain-2 and its cleavage products in postmortem ALS tissue, therapeutic benefit of calpain-2 modulation in animal models of ALS, and the role of calpain-2 in cleaving neurofilament, a broadly researched biomarker in ALS

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Other diabetes drugs may cause hypoglycemia when combined with insulin or insulin secretagogues ( TABLE 1 )