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These agents have demonstrated significant efficacy in reducing cardiovascular events, improving metabolic parameters, and offering protective effects against inflammation and atherosclerosis

estradiol drops, while LH and FSH increase

The SELECT trial demonstrated cardiovascular outcome benefits with FDA-approved semaglutide in a high-risk population

Mean body weight changes across the groups at the end of 32 weeks were: CagriSema: 15.6% Semaglutide alone: 5.1% Cagrilinitide alone: 8.1% [43] Side effects included nausea (29% of patients), diarrhea (16%) and vomiting (10%) in CagriSema treated patients

The recording chamber, with a volume of 500 L, was continuously superfused at a rate of 12 mL/min

Similarly, tirzepatide is more effective at supporting weight loss than semaglutide but seems to have a poorer safety profile