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Unlike MC4R-targeted agonists such as setmelanotide, whose efficacy is intrinsically limited by the functional status of the impaired receptor, GLP-1 RAs operate via pathways largely independent of the leptin-melanocortin circuitry

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Kawasaki I, Shim Y-H, Kirchner J, Kaminker J, Wood WB, Strome S (1998) PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C
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