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In patients with T2DM who are poorly controlled by metformin, increasing DUL from 1.5mg to 3.0mg or 4.5mg can provide glycosylated hemoglobin and weight loss related to clinically relevant doses and has similar safety (111)
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[DOI] [PMC free article] [PubMed] [Google Scholar] 78.Gonzlez LdM et al
Furthermore, the incidence of metabolic syndrome and type 2 diabetes is higher among patients with bipolar disorder than in the general population and is associated with a worse disease course and poor treatment outcomes [187, 188]
The body requires fewer calories to maintain a smaller mass
