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In patients with cardiometabolic #HFpEF, #semaglutide and #tirzepatide reduced the risk of hospitalization for heart failure or all-cause mortality vs sitagliptin, but tirzepatide offered no additional benefit over semaglutide.

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In vitro, mouse pancreatic -cells (NIT-1 cells) were exposed to palmitic acid (PA), PA+exendin-4 (Ex-4), PA+GW, PA+GSK0660 (GSK, a PPAR antagonist), or PA+Ex-4+GSK
