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Participants in the GLP-1 RA cohort had a greater weight and a more preserved renal function at baseline

Table of Contents Then, slowlyor maybe all at oncethe food noise returns

Interestingly, previous analyses have shown that GI side effects may only minimally contribute to weight loss, suggesting that the observed benefits are driven more by pharmacologic rather than AEs

Wilding JP, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MT, Wadden TA, Wharton S

Oral GLP-1 currently represented by Rybelsus (oral semaglutide 7mg/14mg daily) for T2DM and advanced by Eli Lilly's orforglipron in late-stage trials is growing at the fastest route of administration CAGR because it fundamentally removes the injection barrier that constrains GLP-1 therapy adoption in the substantial patient population for whom daily or weekly self-injection is a genuine disincentive to treatment initiation or maintenance

The primary endpoint was the change in cognitive and functional decline measured by the Clinical Dementia Rating Sum of Boxes (CDR-SB) at week 104
