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Decades of research have demonstrated that the brain integrates hormonal, metabolic, cognitive and emotional signals to maintain energy balance, and dysregulation of these neural circuits can lead to conditions such as obesity or eating disorders 1,2

[17] Bitter substances stimulate GIP release to keep blood sugar and appetite under control

The cardiovascular benefits of GLP-1s may be independent of improvements in glycemic control, and in part be driven by reductions in inflammation and cytokine response driving plaque formation in the arterial wall
