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In its official statement, Novo emphasized that the decision was in line with the Supreme Federal Court's own interpretation of ADI 5529, which did not prohibit specific adjustments, only automatic extensions

But their differing efficacy, side-effect profiles, and costs mean that one medication will generally be a better fit depending on the patients clinical profile and lifestyle

Tirzepatides cardiovascular outcomes trial (SURPASS-CVOT) is ongoing as of 2026, so this comparison may change once those results are published

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