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Effects of TZD Use and Discontinuation on Fracture Rates in ACCORD Bone Study

17 We pointed to the evidence that the early use of triple therapy combination of metformin, pioglitazone and a GLP-1 RA achieved lower HbA1c, weight loss and much less hypoglycaemia compared with the traditional approach of sequential escalation through metformin, sulfonylurea and insulin, which was associated with significant weight gain

To assess the influence of follow-up choices and potential informative censoring, we repeated analyses across alternative follow-up windows

That is less than half the volume of the 10 mg/mL version