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The SURMOUNT-5 trial (Rosenstock et al., Lancet 2025) showed 24.2% mean weight loss at 48 weeks, compared to 15.7% for semaglutide 2.4 mg

[10] [11] Comorbidities and cardiovascular risk also factor into decision-making
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Journal of clinical hypertension (Greenwich, Conn) 2016;18(6):51421

Trends Endocrinol Metab 24 , 153163, (2013)

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