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If constipation is severe or persistent, your healthcare provider may consider adjusting the dose escalation schedule or exploring alternative GLP-1 receptor agonists with different gastrointestinal side effect profiles

Griffin WS, Sheng JG, Royston MC, Gentleman SM, McKenzie JE, Graham DI, et al

This gradual elimination is why some patients experience persistent appetite suppression or nausea even after skipping a dosethe medication hasn't fully left their body yet

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Advantage : Retatrutide Research Evidence# CagriSema : Phase 3 REDEFINE program completed with 3,417 participants in REDEFINE 1 and 1,200 in REDEFINE 2