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Outcomes commonly tracked included low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, fasting plasma glucose, insulin, systolic and diastolic blood pressure, C-reactive protein (CRP, an inflammation biomarker), and salivary immunoglobulin A (IgA, an immune biomarker)

[DOI] [Google Scholar] 86.Kashif M., Nasir A., Gulzaman, Rafique M.K., Abbas M., Ur Rehman A., Riaz M., Rasool G., Mtewa A.G

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After an unsuccessful screening of 500,000 discrete small molecules with a GLP-1 competitive binding assay, a substituted quinoxaline was identified in subsequently performed functional screening of 250,000 compounds

The boxed warning applies to the class as a whole based on mechanism of action and rodent toxicology