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Executive Summary Introduction

New data on Hengrui Pharma and Kailera Therapeutics investigational oral GLP-1 have validated the late-stage weight loss asset and paved the road for a regulatory submission in China, but analysts pointed to high rates of nausea and vomiting that could challenge the ongoing U.S

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* BRET : Bioluminescence resonance energy transfer BSA : Bovine serum albumin CyOFP : Cyan-excitable orange fluorescent protein DERET : Diffusion-enhanced resonance energy transfer FCS : Fluorescence correlation spectroscopy FITC : Fluorescein isothiocyanate GFP : Green fluorescent protein GLP-1(R)(A) : Glucagon-like peptide-1 (receptor) (agonist) GUV : Giant unilameller vesicle MCD : Methyl--cyclodextrin Nb37 : Nanobody-37 POPC : 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine T2D : Type 2 diabetes TMR : Tetramethylrhodamine TR-FRET : Time-resolved Frster resonance energy transfer