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The theoretical concern is that a nursing infant exposed to semaglutide through breast milk could experience effects on their own GLP-1 signaling during a critical developmental window

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1 2 Obesity

It binds to the glucagon-like peptide 1 (GLP-1) hormone and potentiates the synthesis and secretion of insulin from pancreatic -cells in a glucose-induced manner (Underwood et al., 2009)

W., Mailhac, A., Lhde, J

Across multiple STEP trials, the enrollment criteria required a BMI of 30 or higher, or 27 or higher with at least one weight-related comorbidity (excluding type 2 diabetes, which was studied separately)