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In nonneuronal tissues, experimental studies have demonstrated that melatonin inhibits NO production induced by lipopolysaccharide (LPS) that induce the activation of the immune response 77

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It can also make it easier to notice changes in hunger and weight gradually, rather than all at once, and to put strategies in place before those changes feel overwhelming

For instance, in a fasted or interprandial state, GLP1 is secreted from enteroendocrine Lcells at low levels (Orskov et al., 1996)

Most researchers notice appetite suppression within the first week

If side effects are problematic, your doctor can discuss alternatives, including: Dose adjustment or slower titration Switching to a different GLP-1 receptor agonist Alternative diabetes medications with different mechanisms of action Additional treatments to manage specific symptoms According to NICE guidance on type 2 diabetes management (NG28), treatment decisions should be individualised, balancing efficacy, side effects, patient preferences, and overall quality of life
