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Desai and Levine reported that weight reductions in GLP-1 RA users were comparable to those observed in non-IBD matched controls [29,36], with greater reductions observed with Tirzepatide [29]

5 Glucose metabolism and insulin sensitivity Several mechanisms related to adrenergic stimulation may influence insulin sensitivity and glucose metabolism

Thr 7 GLP-1 and GIP are partially homologous, in that GIP can partially activate GLP-1R in extreme doses and GLP-1 may also activate GIPR

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The GLP-1 receptor agonist liraglutide was able to reduce Bax expression in pancreatic cells from T2DM rats, and Bcl-2 expression was increased, islet tissue structure was improved, insulin-positive expression was increased, and -cell apoptosis was reduced (Liu et al., 2021)