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Early subcutaneous basal insulin during intravenous insulin infusion for diabetic ketoacidosis (DKA): A systematic review and meta-analysis Our analysis found that adding early basal insulin to standard IV insulin therapy was associated with: 1-Faster DKA resolution 2- Reduced intravenous fluid requirements 3- No increase in hypoglycemia, hypokalemia, recurrent DKA, or mortality 4- An interesting finding was the trend toward a shorter hospital stay in the early basal insulin group

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Phase 1 and Early Development Phase 1 studies in healthy volunteers established proof-of-concept, demonstrating that retatrutide was well-tolerated and produced dose-dependent effects on appetite, food intake, and body weight with acceptable safety profiles

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