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[DOI] [PMC free article] [PubMed] [Google Scholar] 134.Dai Y., Mercanti F., Dai D., Wang X., Ding Z., Pothineni N.V

Although GLP-1RAs can play a favorable role in improving heart failure based on pre-clinical studies, whereas some clinical evidence relevantly have reported that GLP-1RAs treatment could be associated with adverse heart failure events, eg

doi: 10.1111/j.1476-5381.2011.01687.x 106

The clinical result is a coordinated reduction in antral contractility and increased pyloric resistance, leading to prolonged gastric residence times for both liquids and solids [17]

Patients who took tirzepatide lost more weight than those on semaglutide at every measured interval
These trials are mostly based on composite reductions in MACEs (similar to the original ELIXA trial endpoint)
