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October 15, 2025: 133 New Lawsuits Filed for Injuries from Zepbound and Other GLP-1 Drugs Between September and October 2025, 133 lawsuits joined the group litigation for people harmed by Zepbound and other GLP-1 drugs

I watched people in support groups panic because they gained 3 pounds overnight, convinced the medication had stopped working, when it was just normal daily variation

Common Reasons Weight May Increase During Treatment Short-term weight increases during retatrutide treatment are most often caused by normal daily fluctuation, fluid retention, constipation, or inadequate appetite suppression during early dose titration rather than treatment failure

The risk intensifies in the first 48 weeks of therapy when your body is still adjusting to semaglutide's effects

Is this intended to be long-term treatment

No lab work is required by default, and the company reports that labs are requested in fewer than 1 in 1,000 cases