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Consequently, although semaglutide 2.4 mg (Wegovy) had already been approved in 2021 for chronic weight management in adults with obesity or overweight and at least one weight-related condition, the FDA has now expanded this indication to cardiovascular risk reduction in people with concurrent CVD and overweight/obesity

Poor sleep increases cortisol, drives insulin resistance, increases hunger hormones (even partially overriding GLP-1 appetite suppression), and impairs recovery from exercise

These medications may place patients at higher risk for perioperative emesis and pulmonary aspiration

For patients with severe obesity-related complications, providers may lean toward therapies with the strongest efficacy data currently available

However, there was no clear trend for a relationship between creatinine clearance and exposure of liraglutide [41]