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Daily dosing provides consistent hormonal support, avoiding the fluctuations some patients experience with weekly injectable therapies

ESC Heart Failure 11(2):649661 Jalil JE, Gabrielli L, Ocaranza MP, MacNab P, Fernndez R, Grassi B, Jofr P, Verdejo H, Acevedo M, Cordova S et al (2024) New mechanisms to prevent heart failure with preserved ejection fraction using glucagon-like peptide-1 receptor agonism (GLP-1 RA) in metabolic syndrome and in type 2 diabetes: a review

PMCID: PMC11304055

Every 6 to 12 months once stable: After your thyroid levels have stabilized and any levothyroxine dose adjustments have been made, you can return to testing every 6 to 12 months

People in the thread share their personal experiences with Ozempic, emphasizing its effectiveness in managing type 2 diabetes and promoting weight loss

Zepbound May Be Better If: Maximum weight loss is your primary goal SURMOUNT-5 clearly favours it You want more dose flexibility (six strengths to fine-tune tolerance) You also have moderate-to-severe obstructive sleep apnoea with obesity You prefer the cheaper self-drawn vial option via LillyDirect Wegovy May Be Better If: You have established cardiovascular disease Wegovy has an FDA-approved indication to reduce heart attack and stroke risk You dislike injections the oral tablet is now available Your insurance covers Wegovy but not Zepbound (it has been on the market longer and is on more formularies) You respond well to GLP-1-only therapy and tolerate it comfortably What Both Require: Neither drug works in isolation