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doi:10.1055/s-0043-104866 2024 The Author(s)

Side effects are one contributing factor with respect to discontinuation

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Thus, the GCGR-mediated stimulation of cAMP content by retatrutide and the cAMP-induced stimulation of HCN might be reversed by inhibition of cAMP generation through M 2 -cholinceptors and/or A 1 -adenosine receptors