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For example, if morning nausea is an issue, an early morning injection might allow symptoms to ease by bedtime

10.1016/S2213-8587(19)30184-6 8 ArodaV

Overall, while we did not find evidence for many qualitative sex differences in the therapeutic effect of clinically approved GLP-1 analogs, a growing body of literature highlights quantitative sex differences in the response to GLP-1 and its analogs as well as an interaction of these therapeutics with estrogens

Effects of GLP-1 agonists and SGLT2 inhibitors during pregnancy and lactation on offspring outcomes: a systematic review

Transdermal delivery bypasses the GI tract, which could alter both the effective dose range and the side effect profile