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Specifically, GLP-1RAs activate the GLP-1R signaling pathway by crossing the BBB and in various extrahypothalamic regions, such as the cortex, thalamus, hypothalamus, brainstem, and hippocampus [45, 56]

1 The Discovery and Development of Liraglutide and Semaglutide

This is significant because it is the natural site of action of the GLP1-RAs and most relevant to their uses in diabetes and appetite control

BioWorld - Sunday, July 19, 2026 Breaking News: Best of BioWorld Science: Q2See today's BioWorld Science Home Innovent gets IND for oral GLP-1 agonist To read the full story, subscribe or sign in

Interest in triple receptor agonists is climbing fast

If you experience new or worsening symptoms after starting Ozempicsuch as persistent nausea, severe abdominal pain, changes in mood, or signs of hypoglycaemia contact your GP promptly