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Those taking semaglutide had a 14.9% decrease in body weight compared to 2.4% the placebo group

These discrepancies may stem from short observation periods and small sample sizes respectively (101, 102)

The ELIXA trial identified a neutral CV effect of lixisenatide in patients with T2DM and recent acute coronary syndrome

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6.6 When to Refer Referral to a clinician or dietitian may be appropriate when: Persistent GI intolerance limits intake Weight loss exceeds 20% body weight Multiple laboratory abnormalities are present Underlying malabsorptive or gastrointestinal disease exists Patient is elderly or medically complex GLP-1 therapy should not occur in isolation from nutritional oversight when risk factors are present

Microdosing is about fine-tuning GLP-1 signaling, not overpowering it