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Higher preoperative BMI, radical tumor resection, larger preoperative tumor size, hypothalamic tumor invasion, adamantinomatous subtype, and familial predisposition to obesity are cited as factors that increase the risk of HO [49, 52, 53]

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Weight loss as the dominant liver-directed mechanism Pulling these threads together, the most defensible model is that CagriSemas potential liver benefit would be driven predominantly by the sheer size and durability of weight loss it produces, layered on top of semaglutides established metabolic effects, with amylin agonism contributing mainly by amplifying and maintaining that weight loss