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The benefits observed in studies to date depend on achieving and maintaining therapeutic dose ranges over time

The efficacy of RYBELSUS was not impacted by baseline age, sex, race, ethnicity, BMI, body weight, duration of diabetes and degree of renal impairment

[23] Still, faster weight loss from larger deficits seems to result in more lean mass loss, which may be a concern in trained, performance-minded individuals

This was reflected by a large reduction in their PHQ-9 score of 17 points and accompanied by significant improvements in physical health: P2 lost over 11% of their body weight

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Although data from early phase trials suggest that retatrutide is well tolerated with a similar adverse event profile to GLP-1 RAs, additional research assessing long-term safety and efficacy of retatrutide in people living with obesity and/or T2D (including cardiovascular outcomes) is awaited over the next five years