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These engineered cells secreted approximately 15 ng of Ex-4 into the conditioned medium every 24 h, with the peptide released directly into the extracellular environment rather than through extracellular vesicles

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During titration, Michael experienced significant nausea during weeks 2-4 which his provider managed by slowing dose escalation staying at the starting dose for 6 weeks instead of the standard 4

Although there have been conflicting reports on the effects of the incretin class of drugs on the pancreas in animal studies, this is the first study to note such changes in the human pancreas