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Efpeglenatide: The AMPLITUDE-O trial (2021) demonstrated a 27% MACE reduction (HR 0.73, 95% CI 0.580.92) in 4076 T2DM patients, with significant reductions in stroke and HF events [19]

That, together with the Cleveland Clinic studies showing cardiovascular outcome benefits from bariatric surgery, prompted Dr

Due to their weekly dosing schedule and greater mean weight loss seen in trials (15% for semaglutide and 21% for tirzepatide, compared to 8% with liraglutide), semaglutide and tirzepatide are more frequently prescribed than liraglutide for treatment of obesity [33,34,35]

These are subject to provider approval and availability

Ozempic, while also used off-label for weight loss, is primarily prescribed for the management of Type 2 diabetes