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Nutrition therapy is a first-line tool for improving tolerancesmall, frequent meals, adequate hydration, increased fiber, and reduced dietary fat can all make a difference

Kasyanov E, Pinakhina D, Rakitko A, Vergasova E, Yermakovich D, Rukavishnikov G, et al

A patient with specific GLP1R polymorphisms might be a candidate for higher doses, while one with particular FTO variants might benefit from combined GLP-1 and GIP activation

As for safety, the mid-stage trial found Ziihera to be well-tolerated, with only two patients discontinuing treatment due to toxicities

These peptides then increase intestinal glucose-6-phosphotase, ultimately leading to activation of a portal glucose sensor that signals to the brain 59

In practice, American adults take GLP-1s for an average of 6 months
