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Understanding how hormonal regulation of VTA dopaminergic output alters motivated behaviors is essential to leveraging therapeutics that target these hormone systems to treat addiction and disordered eating

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The dosing conditions, schedule and washout period in both studies ensured there was no effect of food or drugdrug interaction between the two drugs evaluated in each study

The exercise creates calorie expenditure that allows higher food intake while maintaining the same net deficit

Several GLP-1Rpositive neuronal populations in different locations could thus be involved, suggesting action on a network of neurons that likely interfaces with multiple aspects of neural energy homeostasis control