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In November 1920 Banting and Best began the process of extracting insulin from islet cells taken from the pancreases of cows and pigs (Hall Jan 2022)

However, individuals with a personal history of medullary thyroid carcinoma or MEN2 should avoid these medications, and those with a family history should consult with a specialist before proceeding

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This guidance reflected the limited evidence available at the time, consisting primarily of case reports and small case series [40]