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Lifestyle changes are key when it comes to naturally boosting GLP-1but sometimes your body needs a little extra support

PMID: 8216285

A separate study from the University of Colorado Anschutz Medical Campus, also using VA data from 21,790 veterans, compared the cardiovascular and kidney safety profiles of three different GLP-1 drugs: liraglutide, semaglutide and dulaglutide
Regulation of glucose homeostasis by GLP-1

van der Valk ME, Mangen M-JJ, Severs M, van der Have M, Dijkstra G, van Bodegraven AA, Fidder HH, de Jong DJ, van der Woude CJ, Romberg-Camps MJL, Clemens CHM, Jansen JM, van de Meeberg PC, Mahmmod N, van der Meulen-de Jong AE, Ponsioen CY, Bolwerk C, Vermeijden JR, Siersema PD, Leenders M, Oldenburg B, COIN study group and the Dutch Initiative on Crohn and Colitis (2016) Evolution of costs of inflammatory bowel disease over two years of follow-up

As DiMarchi points out, 'What you're trying to do is take two individual keys and make a master key that is every bit as effective as the two individual parts.' To their surprise they noticed that mice lost more weight when injected with a balanced dual agonist than when given one more centred on GLP-1