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Therefore, despite its hyperglycemic effects, glucagon triggers lipid catabolism, energy expenditure and reduces food intake

Up to 55% of patients developed anti-drug antibodies [65], which were associated with systemic allergic reactions in approximately 5% of cases and injection-site hypersensitivity, including anaphylaxis, which necessitated early trial termination [66, 67]

No dose management strategy Without clinical oversight, members often stay on high doses far longer than necessary

Hedgehog signaling and steroidogenesis

Table 1 summarized the clinical trials of metformin and TZDs on cognition, MCI, AD, and PD

10.1016/j.clinthera.2005.02.008 14 CarlssonL
